interleukin-18 receptor 1; IL1 receptor-related protein; IL-1Rrp; CD218 antigen-like family member A; CDw218a; CD218a (IL18R1, IL1RRP)

Function

• receptor for IL18
• binding to IL18 leads to the activation of NF-kappa-B
• associates with IL18RAP
• does NOT bind IL1A or IL1B

Structure

• belongs to the interleukin-1 receptor family
• contains 3 Ig-like C2-type domains (immunoglobulin-like)
• contains 1 TIR domain

Compartment

membrane

Expression

• expressed in lung, leukocytes, spleen, liver, thymus, prostate, small intestine, colon, placenta, heart
• NOT expressed in brain, skeletal muscle, pancreas, kidney

Pathology

• high level of expression in Hodgkin's disease cell lines

More general terms

• interleukin receptor
• CD antigen
• glycoprotein

Additional terms

• interleukin-18 receptor accessory protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8809
• OMIM: https://mirror.omim.org/entry/604494
• UniProt: http://www.uniprot.org/uniprot/Q13478.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8809