interleukin-18 receptor accessory protein; IL-18 receptor accessory protein; IL-18RAcP; accessory protein-like; AcPL; CD218 antigen-like family member B; CDw218b; IL-1R accessory protein-like; IL-1RAcPL; interleukin-1 receptor 7; IL-1R-7; IL-1R7; interleukin-18 receptor accessory protein-like; interleukin-18 receptor beta; IL-18R-beta; IL-18Rbeta; CD218b (IL18RAP IL1R7)

Function

• required for the high affinity binding of IL18 to its receptor complex
• in association with IL18R1 mediates IL18-dependent activation of NF-kappa-B & JNK
• does NOT interact directly with IL18
• component of IL-18 receptor complex

Structure

• belongs to the interleukin-1 receptor family
• contains 2 Ig-like C2-type domains
• contains 1 TIR domain

Compartment

• membrane; single-pass type 1 membrane protein (putative)

Expression

• expressed in peripheral blood leukocytes, spleen, lung > colon
• strongly expressed in T-cells polarized with IL12
• coexpressed with IL18R1 in Th1 cells
• induced by IFN-alpha & IL-12 in NK cells & T-cells

More general terms

• CD antigen
• phosphoprotein

Additional terms

• interleukin-18 receptor 1; IL1 receptor-related protein; IL-1Rrp; CD218 antigen-like family member A; CDw218a; CD218a (IL18R1, IL1RRP)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8807
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8807
• OMIM: https://mirror.omim.org/entry/604509
• UniProt: http://www.uniprot.org/uniprot/O95256.html