T helper 1 (Th1)

Function

Production of cytokines:

• IFN-gamma, IFN-alpha
• TNF-beta

in addition to GM-CSF, IL-2, IL-3, IL-10, IL-13 produced by both Th1 & Th2 cells.

Additional functions:

• executes cell-mediated immune responses
  • delayed hypersensitivity
  • macrophage activation
  • immune response to viruses & bacteria

More general terms

• helper T cell (T4 lymphocyte, CD4+)

Additional terms

• granulocyte-macrophage colony-stimulating factor; GM-CSF; colony-stimulating factor 2; molgramostin; sargramostim (CSF2, GMCSF)
• interferon [IFN]-gamma; interferon type 2; immune interferon (IFNG)
• interleukin-10; IL-10; cytokine synthesis inhibitory factor; CSIF (IL10)
• interleukin-13 (IL13, IL-13, NC30)
• interleukin-2; IL-2; T-cell growth factor; TCGF (IL2)
• interleukin-3
• lymphotoxin-alpha; LT-alpha; TNF-beta; tumor necrosis factor ligand superfamily member 1 (LTA, TNFB, TNFSF1)
• macrophage
• type 4 hypersensitivity; T-cell-mediated (delayed) hypersensitivity