interleukin-3; erythrocyte burst-promoting factor; hematopoietic growth factor; mast-cell colony-stimulating factor; multipotential colony-stimulating factor; colony-stimulating factor-2 alpha; mast cell growth factor; P-cell stimulating factor (IL3, IL-3)
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Function
- granulocyte/macrophage colony-stimulating factor
- induces granulocytes, macrophages, mast cells, stem cells, erythroid cells, eosinophils & megakaryocytes
- IL-3 may preferentially participate in expansion of hematopoietic cells in response to inflammatory stimuli rather than constititive hematopoiesis[1]
- predominant growth factor for erythroblast proliferation[2]
Structure
- monomer
- belongs to the IL-3 family
Compartment
Expression
- activated T-cells, mast cells, natural killer cells
More general terms
Additional terms
References
- ↑ 1.0 1.1 UniProt http://www.uniprot.org/uniprot/P08700.html
- ↑ 2.0 2.1 Atlas of Genetics & Cytogenetics in Oncology & Haematology http://atlasgeneticsoncology.org/genes/IL3ID60.html
- ↑ SeattleSNPs http://pga.gs.washington.edu/data/il3/
- ↑ Henderson B & Blake S Therapeutic potential of cytokine manipulation TIPS 13:145 1992 PMID: https://www.ncbi.nlm.nih.gov/pubmed/1589908
- ↑ Medical Knowledge Self Assessment Program (MKSAP) 11, American College of Physicians, Philadelphia 1998
- ↑ Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3562