macrophage colony-stimulating factor 1; CSF-1; M-CSF; MCSF; Lanimostim (CSF1)

Function

• cytokine that induces cells of the monocyte/macrophage lineage
• role in immunological defenses, bone metabolism, lipoprotein clearance, fertility & pregnancy
• glycosylation & proteolytic cleavage yield different soluble forms
• a high molecular weight soluble form is a proteoglycan containing chondroitin sulfate
• isoform 1 is N- & O-glycosylated
• isoform 3 is N-glycosylated
• homodimer or heterodimer; disulfide-linked

Compartment

• cell membrane; single-pass membrane protein
• processed macrophage colony-stimulating factor 1: secreted, extracellular space (putative)

Alternative splicing

named isoforms=3

More general terms

• colony-stimulating factor (CSF)
• oligomerizing protein

Additional terms

• macrophage colony-stimulating factor 1 receptor; CSF-1 receptor; CSF-1-R; CSF-1R; M-CSF-R; proto-oncogene c-Fms; CD115 (CSF1R, FMS)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1435
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1435
• OMIM: https://mirror.omim.org/entry/120420
• UniProt: http://www.uniprot.org/uniprot/P09603.html