interferon [IFN]-alpha
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Function
- antiviral activities
- stimulates the production of two enzymes
- a protein kinase
- oligoadenylate synthetase
Compartment
Pathology
- auto-antibodies to IFN type 1 are present in 0.18% of persons 18-69 years, 1.1% of persons 70-80 years & 3.4% of persons > 80 years[2]
- auto-antibodies to IFN type 1 account for both critical cases of COVID-19 in elderly > 80 years & total COVID-19 mortality[2]
Laboratory
More general terms
More specific terms
- interferon [IFN]-alpha 10; IFN-alpha C; IFN-alpha 6L; LEIF C (IFNA10)
- interferon [IFN]-alpha 14; IFN-alpha H; IFN-lambda 2H; LEIF H (IFNA14)
- interferon [IFN]-alpha 16; IFN-alpha WA (IFNA16)
- interferon [IFN]-alpha 17; IFN-alpha T; IFN-alpha I'; IFN-alpha 88 (IFNA17)
- interferon [IFN]-alpha 1; IFN-alpha 13; IFN-alpha D; LEIF D (IFNA1)
- interferon [IFN]-alpha 21; IFN-alpha F; LEIF F (IFNA21)
- interferon [IFN]-alpha 2; interferon [IFN]-alpha 3; IFN-alpha A; LEIF A (IFNA2)
- interferon [IFN]-alpha 4; IFN-alpha 4B; IFN-alpha M1; IFN-alpha 76 (IFNA4)
- interferon [IFN]-alpha 5; IFN-alpha G; IFN-alpha 61; LEIF G (IFNA5)
- interferon [IFN]-alpha 6; IFN-alpha K; IFN-alpha 54; LEIF K (IFNA6)
- interferon [IFN]-alpha 7; IFN-alpha J; IFN-alpha J1; LEIF J (IFNA7)
- interferon [IFN]-alpha 8; IFN-alpha B; IFN-alpha B2; LEIF B (IFNA8)
- interferon [IFN]-omega 1; IFN-alpha II-1 (IFNW1)
- interferon-alfa
Additional terms
References
- ↑ Henderson B & Blake S Therapeutic potential of cytokine manipulation TIPS 13:145 1992 PMID: https://www.ncbi.nlm.nih.gov/pubmed/1589908
- ↑ 2.0 2.1 2.2 Kwon D Rogue antibodies involved in almost one-fifth of COVID deaths. Nature News. August 31, 2021 https://www.nature.com/articles/d41586-021-02337-5
Bastard P, Gervais A, Le Voyer T et al Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths, Sci Immunol. 2021 Aug 19;6(62):eabl4340. PMID: https://www.ncbi.nlm.nih.gov/pubmed/34413139