ligase or synthetase

Introduction

Enzyme catalyzing the joining together of two molecules with the accompanying hydrolysis of a high-energy bond [synthetase].

More general terms

• enzyme

More specific terms

• 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial; AKB ligase; aminoacetone synthase; glycine acetyltransferase (GCAT, KBL)
• 5-formyltetrahydrofolate cyclo-ligase; 5,10-methenyl-tetrahydrofolate synthetase; methenyl-THF synthetase (MTHFS)
• acetyl CoA carboxylase
• acyl coenzyme-A [CoA] synthetase or acyl coenzyme-A [CoA] ligase
• acyl-CoA synthetase short-chain family member 3, mitochondrial (ACSS3)
• acyl-coenzyme A synthetase ACSM6, mitochondrial (ACSM6, C10orf129)
• adenylosuccinate synthetase isozyme 2 (IMP-aspartate ligase 2, AdSS 2, AMPSase 2, ADSS, ADSS2)
• amino acyl tRNA synthetase
• argininosuccinate synthetase (citrulline-aspartate ligase, ASS1, ASS)
• asparagine synthetase
• biotin-protein ligase; biotin apo-protein ligase; includes: biotin-[methylmalonyl-CoA-carboxytransferase] ligase; biotin-[propionyl-CoA-carboxylase [ATP-hydrolyzing ligase; holocarboxylase synthetase; HCS; biotin-[methylcrotonoyl-CoA-carboxylase] lig...]]
• carbamoyl phosphate synthase
• cytidine triphosphate [CTP] synthase; UTP-NH3 ligase (CTPS)
• DNA ligase
• E3 SUMO-protein ligase NSE2 (non-structural maintenance of chromosomes element 2 homolog, non-SMC element 2 homolog, hMMS21, NSMCE2, C8orf36, MMS21)
• E3 ubiquitin ligase; ubiquitin-ligating enzyme E3; N end-recognizing protein
• fatty acid synthase; includes: [acyl-carrier-protein] S-acetyltransferase; [acyl-carrier-protein] S-malonyltransferase; 3-oxoacyl-[acyl-carrier-protein] synthase; 3-oxoacyl-[acyl-carrier-protein] reductase; 3-hydroxypalmitoyl-[acyl-carrier-protein] deh...
• folylpolyglutamate synthase, mitochondrial; folylpoly-gamma-glutamate synthetase; FPGS; tetrahydrofolylpolyglutamate synthase; tetrahydrofolate synthase (FPGS)
• gamma glutamyl cysteine synthetase
• geranoyl CoA carboxylase
• glutaconyl CoA carboxylase
• glutamate-cysteine ligase; gamma-glutamylcysteine synthetase
• glutamine synthetase; glutamate ammonia ligase (GLUL, GLNS)
• glutamine-dependent NAD+ synthetase; NAD+ synthase [glutamine-hydrolyzing]; NAD+ synthetase 1 (NADSYN1)
• Glutamyl-tRNA(Gln) amidotransferase subunit A homolog (glutaminyl-tRNA synthase-like protein 1, QRSL1)
• glutathione [GSH] synthetase (GSS)
• GMP synthase [glutamine-hydrolyzing]; GMP synthetase; glutamine amidotransferase (GMPS)
• lipoyltransferase 1, mitochondrial; lipoate biosynthesis protein; lipoate-protein ligase; lipoyl ligase (LIPT1)
• methylcrotonoyl CoA carboxylase
• methylmalonyl CoA carboxylase
• monofunctional C1-tetrahydrofolate synthase, mitochondrial (formyltetrahydrofolate synthetase, MTHFD1L, FTHFSDC1)
• multifunctional protein ADE2; phosphoribosylaminoimidazole succinocarboxamide synthase; SAICAR synthetase; phosphoribosylaminoimidazole carboxylase (ADE2, AIRC, PAICS, PAIS)
• NEDD8-activating enzyme E1 catalytic subunit; NEDD8-activating enzyme E1C; ubiquitin-activating enzyme E1C; ubiquitin-like modifier-activating enzyme 3; ubiquitin-activating enzyme 3 (UBA3, UBE1C)
• oxaloacetate carboxylase
• phenylalanyl-tRNA synthetase (phenylalanine-tRNA ligase)
• phenylalanyl-tRNA synthetase beta chain; phenylalanine-tRNA ligase beta chain (PheRS, FARSLB, FARS, FRSB, HSPC173)
• phosphopantothenate-cysteine ligase (phosphopantothenoylcysteine synthetase, PPC synthetase, PPCS, COAB)
• phosphoribosylformylglycinamidine synthase; FGAM synthase; FGAMS; formylglycinamide ribotide amidotransferase; FGARAT; formylglycinamide ribotide synthetase (PFAS, KIAA0361)
• pre-mRNA-processing factor 19 (PRP19/PSO4 homolog, hPso4, nuclear matrix protein 200, senescence evasion factor, PRPF19, NMP200, PRP19, SNEV)
• propionyl CoA carboxylase
• solute carrier family 27 member 1; long-chain fatty acid transport protein 1; fatty acid transport protein 1 (SLC27A1, FATP-1, ACSVL5, FATP1)
• solute carrier family 27 member 3 (SLC27A3, long-chain fatty acid transport protein 3, fatty acid transport protein 3, FATP-3, very long-chain acyl-CoA synthetase homolog 3, VLCS-3, ACSVL3, FATP3, UNQ367/PRO703)
• solute carrier family 27 member 4 (SLC27A4, long-chain fatty acid transport protein 4, fatty acid transport protein 4, FATP-4, ACSVL4, FATP4)
• solute carrier family 27 member 5 (SLC27A5, long-chain fatty acid transport protein 5, bile acyl-CoA synthetase, BACS, bile acid CoA ligase, BA-CoA ligase, BAL, cholate-CoA ligase, very long-chain acyl-CoA synthetase homolog 2, VLCSH2, VLCS-H2, very lo...
• some large E3 complex
• spliceosome
• SUMO ligase E3 (sentrin ligase E3)
• SUMO-conjugating protein-E2 (sentrin-conjugating protein-E2, SUMO carrier protein)
• transcription factor E4F1 (E3 ubiquitin-protein ligase E4F1, E4F transcription factor 1, transcription factor E4F, p120E4F, p50E4F, E4F1, E4F)
• tRNA-splicing ligase RtcB homolog (RTCB, C22orf28, HSPC117)
• tubulin polyglutamylase
• ubiquitin-activating enzyme E1 (ubiquitin-like modifier-activating enzyme 1, A1S9 protein, UBE1, UBA1, A1S9T)
• ubiquitin-activating enzyme E1-like protein 2; monocyte protein 4; MOP-4 (UBE1L2, UBA6, MOP4)
• ubiquitin-conjugating enzyme L-UBC
• ubiquitin-conjugating protein E2 (ubiquitin carrier protein)
• ubiquitin-like 1 [UBL1] activating enzyme E1 (SUMO-1 activating enzyme, UBLE1 ligase)
• urea carboxylase
• vitamin K-dependent gamma-carboxylase; gamma-glutamyl carboxylase; vitamin K gamma glutamyl carboxylase (GGCX, GC)