folylpolyglutamate synthase, mitochondrial; folylpoly-gamma-glutamate synthetase; FPGS; tetrahydrofolylpolyglutamate synthase; tetrahydrofolate synthase (FPGS)

Function

• conversion of folates to polyglutamate derivatives
• this allows tissues to concentrate folate at higher levels than in plasma
• cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis

ATP + tetrahydropteroyl-(gamma-Glu)(n) + L-glutamate
        <-->
ADP + phosphate + tetrahydropteroyl-(gamma-Glu)(n+1)

Structure

• monomer
• belongs to the folylpolyglutamate synthase family

Compartment

mitochondria. cytoplasm

Alternative initiation

named isoforms=2

More general terms

• ligase or synthetase

Database

• UniProt: http://www.uniprot.org/uniprot/Q05932.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2356
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2356
• OMIM: https://mirror.omim.org/entry/136510