adenylosuccinate synthetase isozyme 2 (IMP-aspartate ligase 2, AdSS 2, AMPSase 2, ADSS, ADSS2)

Function

• role in the de novo pathway of purine nucleotide biosynthesis
• nucleotide biosynthesis; AMP biosynthesis; AMP from IMP: step 1/2

GTP + IMP + L-aspartate
       <-->
GDP + phosphate + N(6)-(1,2-dicarboxyethyl)-AMP

Cofactor: binds 1 Mg+2 per subunit (putative)

Structure

• homodimer (putative)
• belongs to the adenylosuccinate synthetase family

Compartment

• cytoplasm
• partially associated with particulate fractions

More general terms

• ligase or synthetase

Database

• UniProt: http://www.uniprot.org/uniprot/P30520.html
• UniProt: http://www.uniprot.org/uniprot/Q8N142.html
• OMIM: https://mirror.omim.org/entry/103060
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=159