solute carrier family 27 member 1; long-chain fatty acid transport protein 1; fatty acid transport protein 1 (SLC27A1, FATP-1, ACSVL5, FATP1)

Function

• involved in translocation of long-chain fatty acids across the plasma membrane
• hormone-regulated in a tissue-specific manner
• in adipocytes, insulin induces a rapid translocation of SLC27A1 from intracellular compartments to the plasma membrane (not so in myocytes); this occurs in parallel with increased LFCA uptake
• may act directly as a bona fide transporter, or in a cytoplasmic or membrane-associated multimeric protein complex to trap fatty acids for accumulation
• role in regulating available LFCA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis
• may be involved in regulation of cholesterol metabolism
• acyl-CoA ligase activity for
  • long-chain fatty acids
  • very long-chain fatty acids

Structure

• self-associates, may function as an homodimer
• belongs to the ATP-dependent AMP-binding enzyme family

Compartment

• plasma membrane & intracellular membranes, at least in adipocytes
• predominantly cytoplasmic in myocytes

Expression

• expressed in muscle & adipose tissue > small intestine > liver

Pathology

• FATP1-mediated fatty acid uptake may be implicated in:
  • insulin resistance
  • fatty acid metabolism & homeostasis
  • obesity

More general terms

• solute carrier family 27 (SLC27, SLC27A)
• transmembrane 2 protein
• mitochondrial protein
• ligase or synthetase

Database

• OMIM: https://mirror.omim.org/entry/600691
• UniProt: http://www.uniprot.org/uniprot/Q6PCB7.html