fatty acid synthase; includes: [acyl-carrier-protein] S-acetyltransferase; [acyl-carrier-protein] S-malonyltransferase; 3-oxoacyl-[acyl-carrier-protein] synthase; 3-oxoacyl-[acyl-carrier-protein] reductase; 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase; enoyl-[acyl-carrier-protein] reductase; Oleoyl-[acyl-carrier-protein] hydrolase (FASN, FAS)
Function
- fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA & NADPH
- multifunctional protein has 7 catalytic activities
- acyl carrier protein
acetyl-CoA + n malonyl-CoA + 2n NADPH = long-chain fatty acid + (n+1) CoA + n CO2 + 2n NADP+
acetyl-CoA + [[[A14342|acyl]]-carrier-protein] = CoA + acetyl-[[[A14342|acyl]]-carrier-protein]
malonyl-CoA + [[[A14342|acyl]]-carrier-protein] = CoA + malonyl-[[[A14342|acyl]]-carrier-protein]
acyl-[[[A14342|acyl]]-carrier-protein] + malonyl-[[[A14342|acyl]]-carrier-protein] = 3-oxoacyl-[[[A14342|acyl]]-carrier-protein] + CO2 + [[[A14342|acyl]]-carrier-protein]
(3R)-3-hydroxyacyl-[[[A14342|acyl]]-carrier-protein] + NADP+ = 3-oxoacyl-[[[A14342|acyl]]-carrier-protein] + NADPH
(3R)-3-hydroxypalmitoyl-[[[A14342|acyl]]-carrier-protein] = hexadec-2-enoyl-[[[A14342|acyl]]-carrier-protein] + H2O
acyl-[[[A14342|acyl]]-carrier-protein] + NADP+ = trans-2,3-dehydroacyl-[[[A14342|acyl]]-carrier-protein] + NADPH
Oleoyl-[[[A14342|acyl]]-carrier-protein] + H2O = [[[A14342|acyl]]-carrier-protein] + oleate
Structure
Compartment
Expression
- ubiquitous
- prominent expression in brain, lung, & liver
Notes
- the relatively low beta-ketoacyl synthase activity may be attributable to the low 4'-phosphopantetheine content of the protein
More general terms
Component of
References
- ↑ UniProt http://www.uniprot.org/uniprot/P49327.html
- ↑ Smith S The animal fatty acid synthase: one gene, one polypeptide, seven enzymes. FASEB J 8:1248 1994 PMID: https://www.ncbi.nlm.nih.gov/pubmed/8001737