GMP synthase [glutamine-hydrolyzing]; GMP synthetase; glutamine amidotransferase (GMPS)

Function

• role in the de novo synthesis of guanine nucleotides
• essential for DNA & RNA synthesis
• essential for providing GTP
• purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1

ATP + xanthosine 5'-phosphate + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate

Structure

• homodimer (putative)
• contains 1 glutamine amidotransferase type-1 domain
• contains 1 GMP-binding domain

Compartment

cytoplasm

Pathology

• chromosomal translocation t(3,11)(q25,q23) involving GMPS with MLL is found in acute myeloid leukemias

More general terms

• ligase or synthetase
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8833
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8833
• OMIM: https://mirror.omim.org/entry/600358
• UniProt: http://www.uniprot.org/uniprot/P49915.html