ubiquitin-activating enzyme E1 (ubiquitin-like modifier-activating enzyme 1, A1S9 protein, UBE1, UBA1, A1S9T)

Function

• catalyzes 1st step of ubiquitin conjugation, ligation of the C-terminal Gly of ubiquitin with Cys within UBE1 (itself), yielding an ubiquitin-E1 thioester & free AMP
• protein degradation; protein ubiquitinylation

Structure

• monomer (putative)
• belongs to the ubiquitin-activating E1 family
• there are 2 active sites within the E1 molecule, allowing it to accommodate 2 ubiquitin moieties at a time, with a new ubiquitin forming an adenylate intermediate as the previous one is transferred to the thiol site

More general terms

• ligase or synthetase
• phosphoprotein

More specific terms

• ubiquitin-like modifier-activating enzyme 5; ubiquitin-activating enzyme 5; thiFP1; UFM1-activating enzyme; ubiquitin-activating enzyme E1 domain-containing protein 1 (UBA5, UBE1DC1)

Additional terms

• NEDD8-activating enzyme E1 catalytic subunit; NEDD8-activating enzyme E1C; ubiquitin-activating enzyme E1C; ubiquitin-like modifier-activating enzyme 3; ubiquitin-activating enzyme 3 (UBA3, UBE1C)
• ubiquitin-activating enzyme E1 homolog (ubiquitin-like modifier-activating enzyme 7, UBA7, UBE2, UBE1L)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7317
• UniProt: http://www.uniprot.org/uniprot/P22314.html
• OMIM: https://mirror.omim.org/entry/314370
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7317