ubiquitin-like modifier-activating enzyme 5; ubiquitin-activating enzyme 5; thiFP1; UFM1-activating enzyme; ubiquitin-activating enzyme E1 domain-containing protein 1 (UBA5, UBE1DC1)

Function

• ubiquitin-activating enzyme E1-like enzyme
• activates UFM1 & SUMO2

Structure

• belongs to the ubiquitin-activating E1 family, UBA5 subfamily

Compartment

• cytoplasm, nucleus
• localizes mainly in cytoplasm
• localizes to the nucleus in presence of SUMO2

Alternative splicing

named isoforms=2

Expression

widely expressed

More general terms

• ubiquitin-activating enzyme E1
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=79876
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:79876
• OMIM: https://mirror.omim.org/entry/610552
• UniProt: http://www.uniprot.org/uniprot/Q9GZZ9.html