small ubiquitin-related modifier 2; SUMO-2; ubiquitin-like protein SMT3B; SMT3 homolog 2; sentrin-2; HSMT3; SUMO-3 (SUMO2, SMT3B, SMT3H2)
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Function
- ubiquitin-like protein which can be covalently attached to target Lys either as a monomer or as a Lys-linked polymer
- does not seem to be involved in protein degradation
- may function as an antagonist of ubiquitin in the degradation process
- plays a role in a number of cellular processes such as
- covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 & linkage to the E2 enzyme UBE2I, & can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4
- polymeric chains can be formed through Lys-11 cross-linking
- cleavage of precursor form by SENP1 or SENP2 is necessary for function
- crystal packing analysis suggests a possible trimeric assembly; biological significance unknown
- interacts with SAE2 & UBE2I
- covalently attached to a number of proteins
- interacts with PELP1
Structure
- homotrimer (putative)
- belongs to the ubiquitin family, SUMO subfamily
- contains 1 ubiquitin-like domain
- SUMO2 & SUMO3 are 95% similar at the amino-terminus
Compartment
nucleus. Note: nuclear bodies
Expression
broadly expressed
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/P61956.html
- ↑ Ye ET et al Ubiquitin-like proteins: new wines in new bottles. Gene 248:1, 2000 PMID: https://www.ncbi.nlm.nih.gov/pubmed/10806345
- ↑ Li Y, Wang H, Wang S, Quon D, Liu YW, Cordell B. Positive and negative regulation of APP amyloidogenesis by sumoylation. Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):259-64. Epub 2002 Dec 27. Erratum in: Proc Natl Acad Sci U S A. 2003 Jul 22;100(15):9102. PMID: https://www.ncbi.nlm.nih.gov/pubmed/12506199