E3 SUMO-protein ligase CBX4; chromobox protein homolog 4; polycomb 2 homolog; Pc2; hPc2 (CBX4)

Function

• E3 SUMO-protein ligase
• facilitates SUMO1 conjugation by UBE2I
• component of polycomb group (PcG) multiprotein PRC1 complex
• protein modification; protein sumoylation
• phosphorylated on Thr-497 by HIPK2 upon DNA damage; which enhances E3 SUMO-protein ligase activity & promotes sumoylation on Lys-494
• interacts with histone H3-K9Me3 (putative)
• interacts with SUV39H1 & HIPK2

Structure

contains 1 chromo domain

Compartment

nucleus

Expression

ubiquitous

More general terms

• chromobox protein homolog
• phosphoprotein

Component of

• Polycomb group multiprotein PRC1 complex (PcG PRC1 complex, hPRC-H, PcG repressive complex 1)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8535
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8535
• OMIM: https://mirror.omim.org/entry/603079
• UniProt: http://www.uniprot.org/uniprot/O00257.html