SUMO-conjugating enzyme UBC9; SUMO-protein ligase; ubiquitin carrier protein 9; ubiquitin carrier protein I; ubiquitin-conjugating enzyme E2 I; ubiquitin-protein ligase I; p18 (UBE2I, UBC9 ,UBCE9)
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Function
- accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3 & SUMO4 from the UBLE1A-UBLE1B E1 complex & catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2 or CBX4
- required for sumoylation of FOXL2 & KAT5
- required for nuclear architecture & chromosomesegregation
- protein modification; protein sumoylation
- interacts with HIPK1, HIPK2, PPM1J, RASD2 & TCF3
- interacts with NR2C1; the interaction promotes its sumoylation
- forms a tight complex with RANGAP1 & RANBP2
- interacts with SIAH1 & PARP
- interacts with various transcription factors such as TFAP2A, TFAP2B, TFAP2C, AR, ETS1 & SOX4
- interacts with RWDD3; the interaction enhances the sumoylation of a number of proteins such as HIF1A & I-kappa-B
- interacts with DNMT1
- interacts with FOXL2
- forms a complex with SENP6 & UBE2I in response to UV irradiation
- interacts with human herpesvirus 6 IE2
- interacts with human adenovirus early E1A protein;
- interaction interferes with polysumoylation (probable)
- interacts with DNM1l (via its GTPase & B domains)
- interaction promotes sumoylation of DNM1L, mainly in its B domain
- interacts with PML-RARA oncoprotein (via coiled-colied domain)
- interaction is required for sumoylation of the PML-RARA oncoprotein
Structure
- belongs to the ubiquitin-conjugating enzyme family
Compartment
- nucleus. cytoplasm
- mainly nuclear
- in spermatocytes, localizes in synaptonemal complexes
- recruited by BCL11A into the nuclear body (putative)
Expression
- expressed in heart, skeletal muscle, pancreas, kidney, liver, lung, placenta & brain
- also expressed in testis & thymus