B-cell lymphoma/leukemia 11A (B-cell CLL/lymphoma 11A, COUP-TF-interacting protein 1, ecotropic viral integration site 9 protein homolog, EVI-9, BCL11A ,CTIP1, EVI9, KIAA1809)
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Function
- myeloid & B-cell proto-oncogene
- roles in leukemogenesis & hematopoiesis
- factor in lymphopoiesis
- required for B-cell formation in fetal liver
- modulates transcriptional repression activity of ARP1 (putative)
- interacts with TFCOUP1, ARP1 & EAR2
Structure
- contains 6 C2H2-type zinc fingers
Compartment
Alternative splicing
named isoforms=7
Expression
- expressed at high levels in brain, spleen thymus, bone marrow & testis
- expressed in CD34-positive myeloid precursor cells, B-cells, monocytes, & megakaryoctes
- expression is tightly regulated during B-cell development
Pathology
- chromosomal translocation t(2;14)(p13;q32.3) involving BCL11A results in BCL11A deregulation & amplification & may be a cause of lymphoid malignancies
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/Q9H165.html
- ↑ Atlas of Genetics and Cytogenetics in Oncology and Haematology http://atlasgeneticsoncology.org/Genes/BCL11AID391.html