dynamin-1-like protein; Dnm1p/Vps1p-like protein; DVLP; dynamin family member proline-rich carboxyl-terminal domain less; Dymple; dynamin-like protein; dynamin-like protein 4; dynamin-like protein IV; HdynIV; dynamin-related protein 1 (DNM1L, DLP1, DRP1)

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Function

Structure

  • the GED domain folds back to interact, in cis, with the GTP-binding domain & middle domain, & interacts, in trans, with the GED domains of other DNM1L molecules, & is thus critical for activating GTPase activity & for DNM1L dimerization
  • belongs to the dynamin family
  • contains 1 GED domain

Compartment

Alternative splicing

named isoforms=6

Expression

Pathology

Comparative biology

More general terms

Additional terms

References

  1. UniProt http://www.uniprot.org/uniprot/O00429.html
  2. 2.0 2.1 Zhang X, Wang R, Hu D et al Oligodendroglial glycolytic stress triggers inflammasome activation and neuropathology in Alzheimer's disease. Science Advances 2020. Vol. 6, no. 49, eabb8680. Dec 4 PMID: https://www.ncbi.nlm.nih.gov/pubmed/33277246 PMCID: PMC7717916 Free PMC article https://advances.sciencemag.org/content/6/49/eabb8680

Database