tetratricopeptide repeat protein 11; mitochondrial fission 1 protein; FIS1 homolog; hFis1; tetratricopeptide repeat protein 11; TPR repeat protein 11 (FIS1, TTC11, CGI-135)

Function

• promotes fragmentation of the mitochondrial network & its perinuclear clustering
• can induce cytochrome c release from the mitochondrion to the cytosoplasm, ultimately leading to apoptosis
• also mediates peroxisomal fission
• ubiquitinated by MARCH5
• interacts with DNM1L/DLP1 through the TPR region
• interacts with MARCH5
• interacts with MID51

Structure

• the C-terminus is required for mitochondrial or peroxisomal localization
• the N-terminus is necessary for mitochondrial or peroxisomal fission, localization & regulation of the interaction with DNM1L
• belongs to the FIS1 family
• contains 1 TPR repeat

Compartment

• mitochondrial outer membrane
• peroxisome membrane

More general terms

• tetratricopeptide repeat protein
• mitochondrial membrane protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=51024
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:51024
• OMIM: https://mirror.omim.org/entry/609003
• UniProt: http://www.uniprot.org/uniprot/Q9Y3D6.html