E3 ubiquitin-protein ligase MARCH5 (membrane-associated RING finger protein 5, membrane-associated RING-CH protein V, MARCH-5, RING finger protein 153, MARCH5, RNF153)

Function

• E3 ubiquitin-protein ligase
• ubiquitin conjugation, 3rd step
• role in the control of mitochondrial morphology
• promotes ubiquitination of DRP1
• interacts with MTFN2 & ubiquitinated forms of DRP1

Structure

• contains 1 RING-CH-type zinc finger, required for E3 ligase activity

Compartment

mitochondrial outer membrane

More general terms

• E3 ubiquitin ligase
• ring finger protein
• mitochondrial membrane protein
• transmembrane 4 protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q9NX47.html