amyloid

Pathology

• insoluble protein/peptide aggregates with a beta pleated sheet conformation
• the beta-pleated sheet gives amyloid the characteristic insolubility & staining properties

Microscopic appearance/staining:

• hematoxylin & eosin: amorphous pink fibrillary aggregates
• Congo red: apple green birefringence seen with polarizing filter, orange red color without polarizing filter
• thioflavin T
• crystal violet (type of methyl violet): metachromatic staining

Laboratory

• amyloid in tissue by light microscopy
  • microscopic observation in tissue by congo red stain
• beta-2-microglobulin amyloid Ag in tissue
• Ig.kappa amyloid Ag in tissue
• Ig.lambda amyloid Ag in tissue
• amyloid P component Ag in tissue
• amyloid A in tissue
  • amyloid A component Ag in tissue
• amyloid precursor protein Ag in tissue
• amyloid.prealbumin Ag in tissue

More general terms

• protein

More specific terms

• A4 amyloid peptide; beta-peptide
• ABri amyloid
• ADan amyloid
• AGel amyloid
• amylin; islet amyloid polypeptide; diabetes-associated peptide; DAP; insulinoma amyloid peptide (IAPP)
• cerebral amyloid
• gamma-trace
• Ig light chain amyloid
• non-A-beta component of AD amyloid
• serum amyloid A-2 protein (SAA2)
• serum amyloid A-4 protein; constitutively expressed serum amyloid A protein; C-SAA (SAA4 CSAA)
• serum amyloid A1 protein; SAA; contains: amyloid protein A; amyloid fibril protein AA (SAA1)
• serum amyloid P component; 9.5S alpha-1 glycoprotein (SAP)

Additional terms

• amyloidosis