cerebral amyloid
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Pathology
- deposition of beta-amyloid in the brain, small & medium size cerebral arteries & the leptomeninges
- cerebral amyloid may precede the onset of Alzheimer's disease (AD) by 20-30 years[1]
Genetics
- old age & apolipoprotein E4 genotype were are associated with cerebral amyloid in adults with & without dementia[1]
Radiology
- neuroimaging negative for cerebral amyloid rules out AD
Complications
More general terms
Additional terms
References
- ↑ Jump up to: 1.0 1.1 1.2 Jansen WJ et al. Prevalence of cerebral amyloid pathology in persons without dementia: A meta-analysis. JAMA 2015 May 19; 313:1924 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/25988462 <Internet> http://jama.jamanetwork.com/article.aspx?articleid=2293295
Ossenkoppele R et al. Prevalence of amyloid PET positivity in dementia syndromes: A meta-analysis. JAMA 2015 May 19; 313:1939 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/25988463 <Internet> http://jama.jamanetwork.com/article.aspx?articleid=2293296
Rosenberg RN et al. Defining amyloid pathology in persons with and without dementia syndromes: Making the right diagnosis. JAMA 2015 May 19; 313:1913. <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/25988459 <Internet> http://jama.jamanetwork.com/article.aspx?articleid=2293276