serum amyloid A1 protein; SAA; contains: amyloid protein A; amyloid fibril protein AA (SAA1)

Function

• major acute phase reactant
• apolipoprotein of the HDL complex
• precursor of amyloid protein A, which is formed by the removal of approximately 24 residues from the C-terminal end

Structure

belongs to the SAA family

Compartment

secreted

Expression

• expressed & secreted into plasma by the liver
• expresse upon cytokine stimulation

Pathology

• reactive, secondary amyloidosis is characterized by extracellular accumulation in various tissues of the SAA protein. these deposits are highly insoluble & resistant to proteolysis; they disrupt tissue structure & compromise function
• elevated serum SSA protein levels may be associated with lung cancer

Polymorphism

• at least 5 different SAA1 alleles have been described: SAA1.1 (SAA1alpha), SAA1.2 (SAA1beta), SAA1.3 (SAA1gamma), SAA1.4 (SAA1delta), SAA1.5 (also named SAA1beta but which differs from SAA1.2

Laboratory

• amyloid A component Ag in tissue

More general terms

• acute phase protein
• amyloid
• glycoprotein

More specific terms

• amyloid protein AA; amyloid fibril protein AA

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6288
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6289
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6288
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6289
• OMIM: https://mirror.omim.org/entry/104750
• OMIM: https://mirror.omim.org/entry/104751
• UniProt: http://www.uniprot.org/uniprot/P0DJI8.html