mitochondrial dynamic protein MID49; mitochondrial dynamic protein of 49 kDa; mitochondrial elongation factor 2; Smith-Magenis syndrome chromosomal region candidate gene 7 protein (MIEF2 MID49 SMCR7)

Function

• mitochondrial outer membrane protein
• regulates mitochondrial fission
• promotes the recruitment & association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 & MFF proteins
• interacts with DNM1L

Structure

belongs to the MID49/MID51 family

Compartment

• mitochondrial outer membrane; single-pass membrane protein
• colocalizes with DNM1L at mitochondrial membrane
• forms foci & rings around mitochondria

Alternative splicing

named isoforms=3

Expression

• expressed in all tissues tested
• highest expression in heart & skeletal muscle

More general terms

• mitochondrial membrane protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=125170
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:125170
• UniProt: http://www.uniprot.org/uniprot/Q96C03.html