calcineurin A-alpha (PPP3CA, calcineurin-A1, phosphatase-2B subunit 1, phosphatase-2B A-alpha subunit)

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Function

calcineurin catalytic subunit
role in calmodulin activation of calcineurin (putative)
interacts with TORC2/CRTC2, MYOZ1, MYOZ2 & MYOZ3

binds 1 Fe+3 ion per subunit
binds 1 Zn+2 per subunit

Structure

belongs to the PPP phosphatase family, PP-2B subfamily

Compartment

nucleus (putative)
colocalizes with ACTN1 & MYOZ2 at the Z line in heart & skeletal muscle

Alternative splicing

named isoforms=2

More general terms

calcineurin-A or phosphatase-3 (2B) catalytic subunit

Additional terms

calcineurin; serine/threonine protein phosphatase 3 (formerly PP2B)

References

↑ Ingebritsen TS, Cohen P. Protein phosphatases: properties and role in cellular regulation. Science. 1983 Jul 22;221(4608):331-8. PMID: https://www.ncbi.nlm.nih.gov/pubmed/6306765
↑ Armstrong DL Calcium channel regulation by calcineurin, a Ca+2-activated phosphatase in mammalian brain TINS 12(3):117 1989 PMID: https://www.ncbi.nlm.nih.gov/pubmed/2469218
↑ Wikipedia, calcineurin entry http://en.wikipedia.org/wiki/calcineurin
↑ UniProt http://www.uniprot.org/uniprot/Q08209.html

Database

UniProt: http://www.uniprot.org/uniprot/Q08209.html
Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5530
OMIM: https://mirror.omim.org/entry/114105

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