alpha-actinin-1; alpha-actinin cytoskeletal isoform; non-muscle alpha-actinin-1; F-actin cross-linking protein (ACTN1)

Function

• F-actin cross-linking protein thought to anchor actin to a variety of intracellular structures
• ACTN1 is a bundling protein

Structure

• homodimer; antiparallel. interacts with DDN, MYOZ2, PDLIM2, TTID & LPP
• belongs to the alpha-actinin family
• contains 1 actin-binding domain
• contains 2 CH (calponin-homology) domains
• contains 2 EF-hand domains
• contains 4 spectrin repeats

Compartment

• cytoplasm, cytoskeleton
• cytoplasm, myofibril, sarcomere, Z-disk
• colocalizes with MYOZ2 & PPP3CA at the Z-line of heart & skeletal muscle

More general terms

• alpha-actinin (ACTN)

Database

• UniProt: http://www.uniprot.org/uniprot/P12814.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=87
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:87
• OMIM: https://mirror.omim.org/entry/102575