myozenin-2 (calsarcin-1, FATZ-related protein 2, MYOZ2, C4orf5)

Function

• myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP & localizing calcineurin signaling to the sarcomere
• role in modulation of calcineurin signaling
• role in myofibrillogenesis
• interacts via its C-terminus with spectrin repeats 3 & 4 of ACTN2
• interacts with ATCN1, LDB3, MYOT & PPP3CA

Structure

• belongs to the myozenin family

Compartment

• colocalizes with ACTN1 & PPP3CA at the Z-line of heart & skeletal muscle

Expression

expressed specifically in heart & skeletal muscle

More general terms

• myozenin (MYOZ)

Database

• OMIM: https://mirror.omim.org/entry/605602
• UniProt: http://www.uniprot.org/uniprot/Q9NPC6.html