alpha-actinin (ACTN)

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Introduction

Actin filament capping protein; caps + end of F-actin to prevent polymerization. alpha-Actinin is a homodimer that also cross- links actin, binds to integrin, vinculin & PI-3-kinase.

More general terms

More specific terms

References

  1. Clark EA & Brugge JS Integrins and signal transduction pathways: the road taken. Science 268:233 1995 PMID: https://www.ncbi.nlm.nih.gov/pubmed/7716514
  2. Wang KK et al Calmodulin-binding proteins as calpain substrates. Biochem J 262:693 1989 PMID: https://www.ncbi.nlm.nih.gov/pubmed/2556106
  3. Molecular Cell Biology (2nd ed) Darnell J; Lodish H & Baltimore D (eds), Scientific American Books, WH Freeman, NY 1990, pg 886