alpha-actinin (ACTN)
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Introduction
Actin filament capping protein; caps + end of F-actin to prevent polymerization. alpha-Actinin is a homodimer that also cross- links actin, binds to integrin, vinculin & PI-3-kinase.
More general terms
More specific terms
- alpha-actinin-1; alpha-actinin cytoskeletal isoform; non-muscle alpha-actinin-1; F-actin cross-linking protein (ACTN1)
- alpha-actinin-2; alpha-actinin skeletal muscle isoform 2; F-actin cross-linking protein (ACTN2)
- alpha-actinin-3; alpha-actinin skeletal muscle isoform 3; F-actin cross-linking protein (ACTN3)
- alpha-actinin-4; non-muscle alpha-actinin 4; F-actin cross-linking protein (ACTN4)
References
- ↑ Clark EA & Brugge JS Integrins and signal transduction pathways: the road taken. Science 268:233 1995 PMID: https://www.ncbi.nlm.nih.gov/pubmed/7716514
- ↑ Wang KK et al Calmodulin-binding proteins as calpain substrates. Biochem J 262:693 1989 PMID: https://www.ncbi.nlm.nih.gov/pubmed/2556106
- ↑ Molecular Cell Biology (2nd ed) Darnell J; Lodish H & Baltimore D (eds), Scientific American Books, WH Freeman, NY 1990, pg 886