filamin C; gamma filamin; filamin-2; actin binding protein-280 autosomal form; protein FLNc; actin-binding-like protein; ABP-L; ABP-280-like protein (FLNC, ABPL, FLN2)

Function

• muscle-specific filamin
• actin-crosslinking protein (putative)
• reorganization of the actin cytoskeleton in response to signaling (putative)
• structural functions at Z-disks in muscle cells (putative)
• interacts with FLNB, KCND2,ITGB1A, INPPL1, MYOT, MYOZ1, MYOZSGCD, SGCG

Compartment

• cytoplasm
• peripheral membrane
• myofibrillar Z-disks
• subsarcolemma

Expression

• expressed in striated muscles > thyroid, fetal brain, fetal lung, retina, spinal cord, bone marrow

Pathology

• silenced in MKN28 & MKN74 gastric cancer cell lines due to aberrant methylation of the gene

More general terms

• filamin (actin-binding protein)

Database

• OMIM: https://mirror.omim.org/entry/102565
• OMIM: https://mirror.omim.org/entry/601419
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2318
• UniProt: http://www.uniprot.org/uniprot/Q14315.html