myozenin-1 (calsarcin-2, filamin-, actinin- & telethonin-binding protein, protein FATZ, MYOZ1, MYOZ)

Function

• myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP & localizing calcineurin signaling to the sarcomere
• role in modulation of calcineurin signaling
• role in myofibrillogenesis
• interacts with ACTN2, ACTN3, FLNA, FLNB, FLNC, LDB3, PPP3CA & TCAP
• interacts via its C-terminal region with MYOT

Structure

• belongs to the myozenin family

Compartment

• localized to nucleus & pseudopodia of undifferentiated cells
• detected throughout myotubes of differentiated cells
• colocalizes with ACTN2, FLNC & MYOT at the Z-lines of skeletal muscle

Expression

• expressed primarily in skeletal muscle
• detected at lower levels in heart, prostate & pancreas

More general terms

• myozenin (MYOZ)

Database

• OMIM: https://mirror.omim.org/entry/605603
• UniProt: http://www.uniprot.org/uniprot/Q9NP98.html