filamin B (beta filamin, actin binding protein-278, thyroid autoantigen, truncated actin-binding protein, truncated ABP, ABP-280 homolog, ABP-278, filamin 3, filamin homolog 1, Fh1, FLNB, FLN1L, FLN3, TABP TAP)

Function

• connects cell membrane constituents to the actin cytoskeleton
• neuroblast migration from the ventricular zone into the cortical plate
• myotube morphology & myogenesis

Compartment

• cytoplasmic, peripheral (isoform 1)
• isoforms 2 & 3 are predominantly localized at actin stress fibers

Alternative splicing

named isoforms=6

Expression

ubiquitous

Pathology

• interaction with FLNA may compensate for dysfunctional FLNA homodimer in the periventricular nodular heterotopia

More general terms

• filamin (actin-binding protein)

Database

• OMIM: https://mirror.omim.org/entry/603381
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2317
• UniProt: http://www.uniprot.org/uniprot/O75369.html