neuroblast; neuronal stem cell
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Introduction
neuronal cell competent to under mitosis
Function
- during development, radial glia & neuronal axons act as physical scaffolds to support neuroblast locomotion
- in adults, neuronal migration is glial-independent since radial glia differentiate into astrocytes after birth
- in adults, neuroblasts are capable of migrating using blood vessels as a scaffold[1]
Compartment
- within the central nervous system, neuroblasts may be found
- within the hilus of the dendate gyrus
- these neuroblasts generate dentate granule neurons
- neurogenesis in the human dentate gyrus ceases by age 13[3]*
- within the subventricular zone
- as interneurons within the olfactory bulb
- molecular layer of the cerebellum giving rise to GABAergic interneurons in rabbits[2]
- granule cell neurogenesis in rabbit cerebellum discontinues prior to puberty[1]
- within the hilus of the dendate gyrus
* Ref[4] claims human neurogenesis persists throughout aging from age 14-79. 2 problems here: 1) this is the period after which ref[3] claims neurogenesis ceases in the human hippocampus
- if neurogenesis were to persist throughout aging from age 14-79 & newly formed granule cells were to accumulate under the older granule cells gradually increasing the thickness of the granule layer, volume of the dentate gyrus should increase throughout aging; ref[4] reports no change in dentate gyrus volume from age 14-79
More general terms
Additional terms
References
- ↑ 1.0 1.1 1.2 Segarra M, Kirchmaier BC, Acker-Palmer A A Vascular Perspective On Neuronal Migration. Mech Dev. 2015 Jul 17. pii: S0925-4773(15)30005-8 PMID: https://www.ncbi.nlm.nih.gov/pubmed/26192337
- ↑ 2.0 2.1 Ponti G, Peretto P, Bonfanti L. Genesis of neuronal and glial progenitors in the cerebellar cortex of peripuberal and adult rabbits. PLoS One. 2008 Jun 4;3(6):e2366. PMID: https://www.ncbi.nlm.nih.gov/pubmed/18523645
- ↑ 3.0 3.1 3.2 Sorrells SF, Paredes MF, Cebrian-Silla A Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults. Nature. April 6, 2018. Published Online March 7, 2018 PMID: https://www.ncbi.nlm.nih.gov/pubmed/29513649 https://www.nature.com/articles/nature25975
- ↑ 4.0 4.1 4.2 Boldrini M, Fulmore CA, Tartt AN et al Human Hippocampal Neurogenesis Persists throughout Aging. Cell Stem Cell. April 5, 2018. 22(4):589 PMID: https://www.ncbi.nlm.nih.gov/pubmed/29625071 https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(18)30121-8