subventricular zone (SVZ)
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Structure
- paired brain structure within the lateral walls of the lateral ventricles
- consists of 4 distinct layers of variable thickness, cell density & cellular composition
- layer 1:
- monolayer of ependymal cells lining lateral ventricle
- layer 2:
- hypocellular layer containing a network of GFAP-positive astrocytic processes linked to junctional complexes
- layer 3:
- ribbon of astrocyte cell bodies
- layer 4:
- transition zone between Layer 3 & the brain parenchyma; contains an abundance of myelin
- layer 1:
* layer 2 as such not comparable in mouse & human[1]
Clinical significance
- along with the dentate gyrus & the olfactory bulb, the SVZ is one of 3 regions of neurogenesis in the adult mammalian brain*
- proliferating neural stem cells in mice may migrate to the olfactory bulb
- far fewer neuroblasts in humans, origin & fate unknown[4]
* In mice, subventricular astrocytes are neural stem cells
Notes
- also see neuroblast
More general terms
References
- ↑ 1.0 1.1 Wikipedia: Subventricular zone https://en.wikipedia.org/wiki/Subventricular_zone
- ↑ Doetsch F et al Subventricular Zone Astrocytes Are Neural Stem Cells in the Adult Mammalian Brain Cell Volume 97, Issue 6, 11 June 1999, Pages 703-716 http://www.sciencedirect.com/science/article/pii/S0092867400807837
- ↑ Alvarez-Buylla A, Garcia-Verdugo JM Neurogenesis in Adult Subventricular Zone Journal of Neuroscience, 1 February 2002, 22(3): 629-634 http://www.jneurosci.org/content/22/3/629.short
- ↑ 4.0 4.1 Sanai N, Berger MS, Garcia-Verdugo JM, Alvarez-Buylla A. Comment on "Human neuroblasts migrate to the olfactory bulb via a lateral ventricular extension". Science. 2007 Oct 19;318(5849):393; author reply 393. PMID: https://www.ncbi.nlm.nih.gov/pubmed/17947566 Free Article