glial fibrillary acidic protein; GFAP (GFAP)
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Classification
- class-3 intermediate filament protein
Function
- inhibits neuronal sprouting
- interacts with SYNM (putative)
- isoform 3 interacts with PSEN1 (via N-terminus)
Structure
- belongs to the intermediate filament family
Compartment
- cytoplasm
- associated with intermediate filaments
Alternative splicing
Expression
- expressed in cells lacking fibronectin
- cells of astroglial lineage
Pathology
- defects in GFAP are a cause of Alexander disease
Laboratory
- GFAP in blood FDA-approved to evaluate mild traumatic brain injury (concussion) in adults
- assessment of need for CT of brain[6]
Notes
- during the development of the central nervous system, distinguishes astrocytes from other glial cells
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/P14136.html
- ↑ Human intermediate Filament mutation Database http://www.interfil.org
- ↑ GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=GFAP
- ↑ Wikipedia; Note: GFAP entry http://en.wikipedia.org/wiki/Glial_fibrillary_acidic_protein
- ↑ Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2670
- ↑ 6.0 6.1 Brooks M FDA Clears First Blood Test to Aid in Concussion Diagnosis. Medscape - Feb 14, 2018. https://www.medscape.com/viewarticle/892683
FDA News Release. Feb 14, 2018 FDA authorizes marketing of first blood test to aid in the evaluation of concussion in adults. https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm596531.htm