synemin; desmuslin (SYNM, DMN, KIAA0353, SYN)

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Function

Structure

Compartment

Alternative splicing

named isoforms=3

Expression

  • isoform 2 is strongly detected in adult heart, fetal skeletal muscles & fetal heart
  • isoform 1 is weakly detected in fetal heart & also in fetal skeletal muscle
  • isoform 1 & isoform 2 are detected in adult bladder (at protein level)
  • the mRNA is predominantly expressed in heart & muscle with some expression in brain which may be due to tissue-specific isoforms
  • in lens
    • first detected at 16 weeks when expression is weakly & uniformly distributed
    • subsequently, expression becomes much stronger in the epithelium of the anterior part at 25 weeks & later
  • in retina
    • weakly expressed at 15 weeks in the nerve fiber layer & ganglion cell layer
    • from 25 weeks onwards, much stronger expression is observed in the endfeet of Mueller cells, the nerve fiber layer, & ganglion cell layer
    • much lower expression is observed in a minor subpopulation of cells in the inner cell layer
    • at 30 & 36 weeks, expression remains in the neural retina, & subsequently becomes stronger in the nerve fiber layer, ganglion cell layer, & inner cell layer & is decreased in Mueller cells
    • at 36 weeks, also expressed at the external border of the outer nuclear layer (at protein level)

More general terms

References

Database