vimentin (VIM)

Function

• class-3 intermediate filament proteins
• phosphoprotein; phosphorylation is enhanced during cell division, at which time vimentin filaments are significantly reorganized
• component of a complex composed at least of ACTB, AP2M1, AP2A1, AP2A2, MEGF10 & VIM
• interacts with LGSN & SYNM (putative)
• belongs to the intermediate filament family

Structure

• homopolymer
• intermediate filament protein

Expression

• highly expressed in fibroblasts, some expression in T-cells & B-cells
• found in various non-epithelial cells, especially mesenchymal cells

Pathology

• little or no expression in Burkitt's lymphoma cell lines
• expressed in many hormone-independent mammary carcinoma cell lines
• interacts with HCV core protein.
• co-expressed with cytokeratins in > 50% of
  • renal cell carcinoma
  • endometrial adenocarcinoma
  • spindle cell carcinoma
  • thyroid follicular carcinoma
  • salivary gland carcinoma
• co-expressed with cytokeratins in < 10% of
  • colorectal adenocarcinoma
  • breast ductal-lobular carcinoma
  • lung non-small cell carcinoma
  • prostate adenocarcinoma
  • endocervical adenocarcinoma

Laboratory

• vimentin Ab in serum
  • mutated citrullinated vimentin Ab in serum

More general terms

• intermediate filament protein
• PEST protein
• oligomerizing protein

Database

• UniProt: http://www.uniprot.org/uniprot/P08670.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7431
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7431
• OMIM: https://mirror.omim.org/entry/193060