actin, cytoplasmic 1; beta-actin (ACTB)

Function

• cytoplasmic actin
• involved in cell motility
• ISGylated
• polymerization of globular actin (G-actin) leads to a structural filament (F-actin)
• ach actin can bind to 4 others
• identified in a mRNP granule complex
• component of the BAF complex
• found in a complex with XPO6, Ran, ACTB & PFN1
• component of the MLL5-L complex
• interacts with XPO6 & EMD

Structure

belongs to the actin family

Compartment

• cytoplasm, cytoskeleton
• localized in cytoplasmic mRNP granules containing untranslated mRNAs

Pathology

• defects in ACTB are a cause of dystonia juvenile-onset

More general terms

• actin
• phosphoprotein

More specific terms

• G-actin

Component of

• mRNP granule complex
• SWI/SNF-A (BAF) chromatin remodeling complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=60
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:60; -.
• OMIM: https://mirror.omim.org/entry/102630
• OMIM: https://mirror.omim.org/entry/607371
• UniProt: http://www.uniprot.org/uniprot/P60709.html