profilin-1; profilin I (PFN1)

Function

• binds to actin & affects the structure of the cytoskeleton
• modulates polymerization of actin; inhibits high but enhances at low concentrations
• by binding to PIP2, inhibits formation of IP3 & diacylglycerol
• occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio
• found in a complex with XPO6, Ran, ACTB & PFN1

Structure

belongs to the profilin family

Compartment

cytoplasm, cytoskeleton

More general terms

• profilin

Database

• UniProt: http://www.uniprot.org/uniprot/P07737.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5216
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5216
• OMIM: https://mirror.omim.org/entry/176610