alpha-1 adaptin; AP-2 complex subunit alpha-1; adapter-related protein complex 2 alpha-1 subunit; adaptor protein complex AP-2 subunit alpha-1; alpha1-adaptin; plasma membrane adaptor HA2/AP2 adaptin alpha A subunit; alpha-adaptin A; clathrin assembly protein complex 2 alpha-A large chain; 100 kD coated vesicle protein A (AP2A1, ADTAA, CLAPA1)
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Function
- subunit of clathrin-associated adaptor protein complex 2 (HA2-AP2 adaptor complex)
- interacts with RAB11FIP2
- component of a complex composed at least of ACTB, AP2M1, AP2A1, AP2A2, MEGF10 & VIM
Structure
- belongs to the adaptor complexes large subunit family
Compartment
- Golgi
- cytoplasmic vesicle
- clathrin-coated vesicle membrane
- peripheral membrane, cytoplasmic side (putative)
- component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex (putative)
Alternative splicing
named isoforms=2
Expression
- isoform A expressed in forebrain, skeletal muscle, spinal cord, cerebellum, salivary gland, heart & colon
- isoform B is widely expressed in tissues & also in breast cancer & in prostate carcinoma cells
More general terms
Additional terms
Component of
References
- ↑ UniProt http://www.uniprot.org/uniprot/O95782.html
- ↑ Serafini T et al A coat subunit of Golgi-derived non-clathrin-coated vesicles with homology to the clathrin-coated vesicle coat protein beta-adaptin. Nature. 1991 Jan 17;349(6306):215-20. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1898984