AP-2 complex subunit mu-1; adaptor protein 50; adaptin-mu2; AP-2 mu-2 chain; plasma membrane adaptor AP-2 50 kD protein; HA2 50 kD subunit; clathrin assembly protein complex 2 medium chain; clathrin coat assembly protein AP50; clathrin coat-associated protein AP50 (AP2M1, CLAPM1, KIAA0109)

Function

• component of HA2/AP2 adaptor complex (AP-2)
• component of a complex composed at least of ACTB, AP2M1, AP2A1, AP2A2, MEGF10 & VIM
• interacts with ATP6V1H & MEGF10
• phosphorylated (putative)

Structure

• belongs to the adaptor complexes medium subunit family
• contains 1 MHD (mu homology) domain

Compartment

• cell membrane, coated pit
• peripheral membrane, cytoplasmic side
• component of coat surrounding the cytoplasmic face of coated vesicles in the plasma membrane

Alternative splicing

named isoforms=2

More general terms

• mu adaptin (adaptor-related protein complex, mu subunit)
• phosphoprotein

Additional terms

• HA2/AP2 adaptor complex

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1173
• OMIM: https://mirror.omim.org/entry/601024
• UniProt: http://www.uniprot.org/uniprot/Q96CW1.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1173