talin-1 (TLN1, KIAA1027, TLN)
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Function
- role in connections of major cytoskeletal structures to the plasma membrane
- binds to side of F-actin filament so that both + (barbed) & - (pointed) ends are free
- binds with high affinity to vinculin & with low affinity to integrins
- interacts with PIP5K1C & NRAP
- interacts with LAYN
- interacts with SYNM
Structure
- contains 1 FERM domain
- contains 1 I/LWEQ domain
Compartment
- cell projection, ruffle membrane
- peripheral membrane protein; cytoplasmic side (putative)
- cytoplasm, cytoskeleton (putative
- colocalizes with LAYN at the membrane ruffles (putative)
- concentrated at regions of cell-substratum contact &, in lymphocytes, at cell-cell contacts
More general terms
Additional terms
References
- ↑ Molecular Cell Biology (2nd ed) Darnell J; Lodish H & Baltimore D (eds), Scientific American Books, WH Freeman, NY 1990, pg 923
- ↑ Bishop JM. Molecular themes in oncogenesis. Cell. 1991 Jan 25;64(2):235-48. Review. No abstract available. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1988146
- ↑ Stossel TP. On the crawling of animal cells. Science. 1993 May 21;260(5111):1086-94. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8493552
- ↑ Clark EA & Brugge JS Integrins and signal transduction pathways: the road taken. Science 268:233 1995 PMID: https://www.ncbi.nlm.nih.gov/pubmed/7716514
- ↑ UniProt http://www.uniprot.org/uniprot/Q9Y490.html