phosphatidylinositol-4-phosphate 5-kinase type-1 gamma; PIP5K1-gamma; Ptdins(4)P-5-kinase 1 gamma; phosphatidylinositol-4-phosphate 5-kinase type I gamma; PIP5KIgamma (PIP5K1C, KIAA0589)

Function

• synpatic membrane ruffling & assembly of clathrin-coated pits at the synapse
• RAC1-dependent reorganization of actin filaments
• biosynthesis of phosphatidylinositol-4,5-bisphosphate.
• interacts with TLN1, TLN2, CSK, ARF6, AP2B1
• activated by interaction with TLN2
• interacts with AP2M1
  • phosphorylation of PIP5K1C by CSK disrupts the interaction
  • clathrin competes with PIP5K1C (putative)

ATP + phosphatidyl-inositol-4-phosphate = ADP + phosphatidyl-inositol-4,5-bisphosphate

Structure

contains 1 PIPK domain

Compartment

• plasma membrane, cytoplasmic side
• detected in focal adhesion plaques, membrane ruffles & plasma membrane invaginations

Pathology

• defects in PIP5K1C are the cause of lethal congenital contracture syndrome type 3

More general terms

• phosphoinositide-5-kinase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=23396
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:23396
• OMIM: https://mirror.omim.org/entry/606102
• OMIM: https://mirror.omim.org/entry/611369
• UniProt: http://www.uniprot.org/uniprot/O60331.html