ADP-ribosylation factor 6 (ARF6)

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^[1]^[2]^[3]^[4]

Function

GTP-binding protein
activates ADP-ribosyltransferase (putative)
role in protein trafficking
may modulate vesicle budding & uncoating within the Golgi
may function in receptor-mediated endocytosis^[3]
interacts with ARHGAP21, ASAP2, HERC1, PIP5K1C & UACA

Structure

belongs to the small GTPase superfamily, Arf family

Compartment

Golgi apparatus

Pathology

allosteric activator of the cholera toxin catalytic subunit

More general terms

ADP-ribosylation factor [ARF] subfamily protein

References

↑ UniProt http://www.uniprot.org/uniprot/P62330.html
↑ Kahn RA, Der CJ, Bokoch GM. The ras superfamily of GTP-binding proteins: guidelines on nomenclature. FASEB J. 1992 May;6(8):2512-3. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1592203
↑ ^3.0 ^3.1 D'Souza-Schorey C, Li G, Colombo MI, Stahl PD. A regulatory role for ARF6 in receptor-mediated endocytosis. Science. 1995 Feb 24;267(5201):1175-8. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7855600
↑ Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=382

Database

UniProt: http://www.uniprot.org/uniprot/P62330.html
Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=382
Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:382
OMIM: https://mirror.omim.org/entry/600464

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