ADP-ribosylation factor [ARF] subfamily protein
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Function
- necessary for efficient ADP-ribosylation of Gs-alpha by cholera toxin
- role in membrane vesicle fusion & transport
- role in endoplasmic reticulum (ER) to GOLGI transport, intra-GOLGI transport, nuclear vesicle fusion, endosome fusion & receptor-mediated endocytosis Strucure:
- all currently known ARF subfamily proteins have a Gly at position 2, are N-myristoylated, & lack a Cys near the C-terminus (thus no CaaX motif)
- the ARF subfamily consists of 15 structurally-related gene products that include:[5]
- 6 ARF proteins
- 11 ARF-like proteins
More general terms
More specific terms
- ADP-ribosylation factor 1 (ARF1)
- ADP-ribosylation factor 3 (ARF3)
- ADP-ribosylation factor 4 (ARF4, ARF2)
- ADP-ribosylation factor 5 (ARF5)
- ADP-ribosylation factor 6 (ARF6)
- ADP-ribosylation factor 7 (ADP-ribosylation factor-like protein 14, ARL14, ARF7)
- ADP-ribosylation factor-2 (arf2)
- ADP-ribosylation factor-like protein (ARL)
References
- ↑ Kahn RA, Der CJ, Bokoch GM. The ras superfamily of GTP-binding proteins: guidelines on nomenclature. FASEB J. 1992 May;6(8):2512-3. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1592203
- ↑ Boguski MS & McCormick F Proteins regulating Ras and its relative. Nature 366:643 1993 PMID: https://www.ncbi.nlm.nih.gov/pubmed/8259209
- ↑ Bourne HR et al, The GTPase superfamily: a conserved switch for diverse cell functions Nature 348:125 1990 PMID: https://www.ncbi.nlm.nih.gov/pubmed/2122258
- ↑ Orcl L, Palmer DJ, Amherdt M, Rothman JE. Coated vesicle assembly in the Golgi requires only coatomer and ARF proteins from the cytosol. Nature. 1993 Aug 19;364(6439):732-4. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8355790
- ↑ 5.0 5.1 D'Souza-Schorey C, Li G, Colombo MI, Stahl PD. A regulatory role for ARF6 in receptor-mediated endocytosis. Science. 1995 Feb 24;267(5201):1175-8. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7855600