ADP-ribosylation factor 1 (ARF1)
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Function
- GTP-binding protein
- role in protein trafficking among different compartments
- modulates vesicle budding & uncoating within the Golgi complex
- role in initial step of assembly & budding of COP-coated vesicles mediating intercisternal GOLGI transport
- deactivation induces redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking
- in its GTP-bound form, triggers association with coat proteins with the Golgi membrane
- hydrolysis of ARF1-bound GTP, mediated by ARFGAPs, is required for dissociation of coat proteins from Golgi membranes & vesicles
- interacts with PRKCABP, GGA1, ASAP2 & PIP5K1A
- ARFGAP1 hydrolyzes ARF1-GTP & regulates its function
- binds ASAP2
- interacts with HERC1 & ARHGAP21
Structure
belongs to the small GTPase superfamily, Arf family
Compartment
Pathology
- allosteric activator of the cholera toxin catalytic subunit
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/P84077.html
- ↑ Kahn RA, Der CJ, Bokoch GM. The ras superfamily of GTP-binding proteins: guidelines on nomenclature. FASEB J. 1992 May;6(8):2512-3. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1592203
- ↑ D'Souza-Schorey C, Li G, Colombo MI, Stahl PD. A regulatory role for ARF6 in receptor-mediated endocytosis. Science. 1995 Feb 24;267(5201):1175-8. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7855600
- ↑ Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=375