ADP-ribosylation factor GTPase-activating protein 1; ARF GTPase activating protein 1; ARF GAP 1; ADP-ribosylation factor 1 GTPase-activating protein; ARF1 GAP; ARF1-directed GTPase-activating protein (ARFGAP1, ARF1GAP, ASAP1, DDEF1, KIAA1249)

Function

• GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1)
• role in membrane trafficking & /or vesicle transport
• promotes hydrolysis of the ARF1-bound GTP & is required for dissociation of coat proteins from Golgi-derived membranes & vesicles, a prerequisite for vesicle's fusion with the target compartment
• probably regulates ARF1-mediated transport via interaction with the KDELR proteins & TMED2
• overexpression induces redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated
• activity is stimulated by phosphoinosides
• interacts with ARF1
• interacts with the COPI coat proteins, KDELR1 & TMED2
  • interaction with TMED2 inhibits the GAP activity (putative)

Inhibition:

• inhibited by phosphatidylcholine (putative)

Structure

• the region downstream of Arf-GAP domain is essential to GAP activity in vivo
  • this region may be required for its targeting to Golgi membranes (putative)
• contains 1 Arf-GAP domain

Compartment

• cytoplasm (putative)
• Golgi apparatus (putative)
• associates with the Golgi complex

Alternative splicing

named isoforms=3

More general terms

• ADP-ribosylation factor GTPase activating protein (ARF-GAP)
• zinc finger protein
• ankyrin repeat domain protein (ANKRD)

Additional terms

• Arf-GAP with SH3 domain, ANK repeat & PH domain-containing protein 1

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=55738
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:55738
• OMIM: https://mirror.omim.org/entry/608377
• UniProt: http://www.uniprot.org/uniprot/Q8N6T3.html