Arf GTPase-activating (Arf-GAP) domain

Introduction

Involved in hydrolysis of GTP bound to ARF.

Consists of a 3-stranded beta-sheet surrounded by 5 alpha helices. The domain is organized around a central Zn+2 coordinated by 4 cysteines. The zinc finger motif has some similarity to the C4-type GATA zinc finger.

More general terms

• GTPase-activating (GAP) domain