Arf-GAP with SH3 domain, ANK repeat & PH domain-containing protein 1; 130 kD phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein; ADP-ribosylation factor-directed GTPase-activating protein 1; ARF GTPase-activating protein 1; development & differentiation-enhancing factor 1; DEF-1; differentiation-enhancing factor 1; PIP2-dependent ARF1 GAP (ASAP1, DDEF1, KIAA1249)
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Function
- possesses phosphatidylinositol-4,5-bisphosphate dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) & ARF5 & lesser activity towards ARF6
- may coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC & PIP2
- may function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes & possibly other cell types (putative)
- role in ciliogenesis activity stimulated by phosphatidylinositol-4,5-bisphosphate (PIP2) (putative)
- phosphorylated on Tyr by SRC (putative)
- homodimer
- interacts with SRC & CRK
- interacts with RAB11FIP3
- interacts with PTK2B/PYK2 (putative)
- interacts with CTTN
- interacts (via SH3 domain) with APC
Structure
- the PH domain most probably contributes to the phosphoinositide-dependent regulation of ADP ribosylation factors
- contains 2 ANK repeats
- contains 1 Arf-GAP domain
- contains 1 PH domain
- contains 1 SH3 domain
Compartment
- cytoplasm (putative), membrane
- predominantly cytoplasmic (putative)
- partially membrane-associated (putative)
Alternative splicing
named isoforms=2