Src substrate cortactin; amplaxin; oncogene EMS1 (CTTN EMS1)
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Function
- organization of cell structure
- associated with actin/integrin focal contacts
- may associate with Shank at the post synaptic density[3]
- substrate for the pp60v-src tyrosine kinase
- role in synaptic plasticity by mediating the local assembly of cytoskeleton & interacting with the NMDA receptor & PSD-95[4]
- SH3 motif may function as a binding region to cytoskeleton
- interacts with SHANK2 & SHANK3 via its SH2 domain
- interacts with FGD1 (putative)
- interacts with PLXDC2
Structure
- contains 7 cortactin repeats
- contains 1 SH3 domain
Compartment
- cytoplasm, cytoskeleton (putative)
- cell projection, lamellipodium (putative)
- cell projection, ruffle (putative)
- associated with membrane ruffles & lamellipodia (putative)
Pathology
- Tyr phosphorylation in transformed cells may contribute to cellular growth regulation & transformation
More general terms
References
- ↑ Stossel TP. On the crawling of animal cells. Science. 1993 May 21;260(5111):1086-94. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8493552
- ↑ T. Maciag Holland Laboratory, American Red Cross, Bethesda, MD
- ↑ 3.0 3.1 Sheng M. Molecular organization of the postsynaptic specialization. Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7058-61. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11416187
- ↑ 4.0 4.1 Rampon C, Jiang CH, Dong H, Tang YP, Lockhart DJ, Schultz PG, Tsien JZ, Hu Y. Effects of environmental enrichment on gene expression in the brain. Proc Natl Acad Sci U S A. 2000 Nov 7;97(23):12880-4. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11070096
- ↑ UniProt http://www.uniprot.org/uniprot/Q14247.html
- ↑ Wikipedia; Note: cortactin entry http://en.wikipedia.org/wiki/cortactin